DNA Methylation Pathway Profile

Preparation & Timing  

• No special preparation is needed.
• Do not collect if you are sick. 

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Collection Instructions

1. Rinse your mouth with cold water.
2. Open one of the sleeves and remove one swab. 
   1. Keep the package intact.
   2. Only peel it open enough to remove the applicator.
   
3. Remove ONE cotton swab applicator.
   1. Do NOT touch the cotton tip.
4. Swallow to remove excess saliva.
5. Using a circular motion, rub the swab on the inside of one cheek about 20 times. 
   1. Use enough pressure for the cheek to be pushed outward.
6. Gently wave the swab in the air to let it dry for 3 minutes. 
   1. Do NOT touch the swab.
7. Once the swab is dry, place it back in the sleeve.
8. Remove the second swab from the sleeve.
9. Repeat steps 4-8 for the second swab. 
   1. Use the same cheek. 
10. Once you have completed the first set of swabs, open the other sleeve. 
11. Repeat steps 2-9 for the second two swabs. 
    1. Use the other cheek. 

    Example
    1st swab	Right cheek
    2nd swab	Right cheek
    3rd swab	Left cheek
    4th swab	Left cheek

12. Once all four samples have been collected, place the two sleeves containing the four dry swabs in the provided Swab Collection Return Envelope. 
    1. Do NOT place the swabs in a plastic bag.

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Requisition & Payment

• Your kit has been prepaid. You DO NOT need to pay anything extra.
• Instructions on how to fill out your requisition can be found HERE.
  • Since you pre-paid for your tests, you do not need to fill in the payment information on any of these forms.
  • DO NOT fill out any information on gplforms.com.

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Shipping

• Ship samples as soon as possible after collection. 
• To prepare your samples for shipping, 
  • Place the two swab-containing sleeves into the provided Swab Collection Return Envelope.
  • Seal the envelope.
  • Place the Swab Collection Return Envelope into the provided FedEx envelope. 
  • Place the completed test requisition form into the FedEx envelope.
  • Place the Informed Consent form into the FedEx envelope.
  • Seal the envelope. 
• Make a note of the tracking number so that you can track your sample back to the lab.
• Ship your samples via FedEx. 
  • You can take your samples to the nearest FedEx location.
  • DO NOT place your samples in a FedEx drop box. 
  • You can also schedule a FedEx pickup by calling 1-800-463-3339. 
    • At the automated greeting, say, "schedule a pickup."
    • At the next prompt, say, "schedule a pickup with a label or stamp." 
    • You will be asked if the waybill says "stamp" - say, "yes."
    • Then give your address information. 

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Results

• Results should be released to your provider 5-6 weeks after samples are received at the lab. We cannot guarantee processing time. 
• Your provider will notify you when your results are in and schedule a follow-up appointment for you to review them together. 
• Your provider may choose to release your results to you. Rupa cannot release your results without provider authorization.

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More Resources

• DNA Methylation Pathway Profile Info Page
• The Great Plains Laboratory Patient FAQ
• [PDF] How to Collect Your Sample

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Questions?

For general questions, email Rupa Health at support@rupahealth.com. For test-specific questions, contact The Great Plains Laboratory by calling 1-800-288-0383 or chatting with support.