Cortisol, Salivary

Test Details

Lab Company: Genova Diagnostics
Sample Type: Saliva
Collection Location: At Home

This test measures morning cortisol.      

🔑 Key Details 📦 Shipping
Preparation & Timing 📊 Results
🧪 Collection Instructions 📚 More Resources
💳 Requisition & Payment
💬 Questions?

Key Details 

  • Do NOT register your test online with Genova.
  • You must avoid certain activities for 1 hour prior to collection. 
  • Keep your sample in the freezer until you ship it. 
  • Ship your sample as soon as possible, Monday - Thursday only.

back to top

Preparation & Timing

  • If you are taking or have taken any of these medications in the past 12 months, consult your healthcare provider prior to taking this test. They may produce artificially high results. 
    • Sublingual hormones
    • Transdermal hormones
  • If you have taken any of the following herbs, supplements, or drugs in the past 3 months, consult your healthcare provider prior to taking this test. They may affect results. 
    • Ketoconazole
    • Cimetidine (Tagamet)
    • Anastrozole (Arimidex)
    • Letrozole (Femara)
    • Exemestane (Aromasin)
    • Chrysin
    • Apigenin
    • Tribulus terrestris
    • Clomiphene
    • Antiepileptics
    • Digoxin
    • Oral steroids (e.g. Prednisone)
    • Cortisone cream
    • Steroid-based nasal sprays, inhalers, or eye drops 
  • Avoid the following activities for 1 hour prior to each collection. 
    • Eating
    • Brushing your teeth
    • Flossing your teeth
    • Using mouthwash
    • Chewing gum
    • Using tobacco products  

back to top

Collection Instructions

  1. You will collect your sample soon after waking - between 7:00 am and 9:00 am.  
  2. Fill the tube with saliva to the FILL LINE (3 mL mark). 
    1. Your sample should reach the FILL LINE (not including bubbles).
    2. Avoid getting mucus in your sample. 
  3. If you have trouble producing enough saliva, try
    1. Pressing your tongue against the roof of your mouth
    2. Yawning
    3. Thinking about your favorite food
  4. Place the cap tightly on the tube.
  5. Write the following information on the tube label and test requisition form. 
    1. Patient's first and last name
    2. Patient's date of birth
    3. Date of collection
    4. Time the collection started
    5. Time the collection ended
  6. Place the tube in the biohazard bag.
  7. Freeze the tube (in the bag) immediately.
    1. The sample should be frozen for at least 2 hours prior to shipping.
    2. The sample must remain frozen until it is shipped. 

back to top

Requisition & Payment

  • Your kit has been prepaid. You DO NOT need to pay anything extra.
  • Instructions on how to fill out your requisition can be found HERE (insurance pay) and HERE (cash pay).
    • Since you pre-paid for your tests, you do not need to fill in the payment information on any of these forms.
    • DO NOT register your test online with Genova.

back to top


  • Ship your sample as soon as possible, Monday - Thursday only.
  • To prepare your sample for shipping,
    • Place the tube in the biohazard bag immediately after collection.
    • Place the tube (in the bag) in the freezer.
    • Leave the tube in the freezer for at least 2 hours. 
    • When ready to ship, remove your sample tube from the freezer. 
    • Place the biohazard bag in the test kit box.
    • Place the test kit box in the provided FedEx Clinical Pak.
    • Place the completed test requisition form in the Clinical Pak. 
  • Make a note of the return tracking number so that you can track your sample back to the lab. 
  • Ship your sample via FedEx.
    • You can take your sample to the nearest FedEx location.
    • Do NOT place your sample in a drop box.
    • You can schedule a pickup by calling FedEx at 1-800-463-3339 or visiting

back to top


  • Results should be released to your provider 7-21 business days after samples are received at the lab. We cannot guarantee processing time. 
  • Your provider will notify you when your results are in and schedule a follow-up appointment for you to review them together. 
  • Your provider may choose to release your results to you. Rupa cannot release your results without provider authorization.

back to top

More Resources

back to top


For general questions, email Rupa Health at For test-specific questions, contact Genova Diagnostics by calling 800-522-4762 or chatting with support