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Lab Test Instructions
Genova Diagnostics
Methylation Add On: Methylation Genomics
Methylation Add On: Methylation Genomics
Updated over a week ago

Test Details

Lab Company: Genova Diagnostics
โ€‹ Sample Type: Swab
โ€‹ Collection Location: At Home

The Methylation Genomics add-on provides a measurement and analysis of genetic single nucleotide polymorphisms (SNPs) for a deeper understanding of methylation.

Key Details

  • This test is an add-on to the Methylation Panel test.

  • Sample collection should be performed prior to your blood draw.

  • You must avoid certain activities the night before and the day of sample collection.

  • Your sample should be collected immediately upon rising.

  • Bring your samples to your blood draw appointment.

  • Rupa Health recommends shipping your samples Monday - Thursday only to avoid shipment delays

Preparation & Timing

  • Sample collection should be performed prior to your blood draw.

  • If you are taking any of the following medications, consult your healthcare provider regarding timing.

    • SAM-e supplements

    • Amino acid supplements

    • Non-essential nutritional supplements

  • The night before collection

    • DO NOT use mouthwash.

  • The morning of collection

    • DO NOT eat anything.

    • DO NOT drink anything.

    • DO NOT brush your teeth.

    • DO NOT floss your teeth.

  • Your sample should be collected immediately upon rising.

Collection Instructions

  1. Collect your samples immediately upon waking (before eating, drinking, brushing your teeth, etc.).

  2. Thoroughly wash your hands with soap and warm water.

  3. Dry your hands with a clean towel.

  4. Gently peel open the package labeled "Sterile Cotton Tipped Applicator."

    1. Keep the package intact.

    2. Only peel it open enough to remove the applicator.

  5. Remove ONE cotton swab applicator.

    1. DO NOT touch the cotton tip.

  6. Open your mouth widely.

  7. Insert the cotton tip of the swab applicator.

  8. Aggressively scrape the inside of your cheek for at least 30 seconds.

    1. Use a back and forth, up and down motion.

    2. Rotate the applicator several times.

    3. Swab between the cheek and gums.

    4. Avoid excessive saliva.

  9. Allow the swab to air dry for 15-20 minutes.

    1. DO NOT let the cotton tip touch any surface or your hands.

  10. Repeat steps 5-9 with the second swab.

  11. Complete the test registration (instructions HERE).

    1. Please ensure that the name on the registration matches the name on your Rupa order EXACTLY. If it does not match, you may need to recollect your samples.

  12. Once the swabs have dried, place them back into the applicator package, cotton tip first.

  13. Write the following information on the label and place it on the envelope.

    1. Patient's full name

    2. Patient's date of birth

  14. Insert the swab applicator package into the provided envelope and seal.

  15. Bring the envelope to your blood draw appointment.

Requisition & Payment

  • Your kit has been prepaid. You DO NOT need to pay anything extra.

  • Instructions on how to complete test registration can be found HERE.

    • Since you pre-paid for your tests, you do not need to fill in the payment information on this form.


  • Make a note of the tracking number on the return mailer so that you can track your samples back to the lab.

  • Bring your swabs to your blood draw appointment.

  • The phlebotomist will ship the swab samples with the blood samples.

    • Rupa Health recommends getting your blood drawn and samples shipped Monday - Thursday only to avoid shipment delays.


  • Results should be released to your provider 7-21 business days after samples are received at the lab. We cannot guarantee processing time.

  • Your provider will notify you when your results are in and schedule a follow-up appointment for you to review them together.

More Resources


For general questions, email Rupa Health at For test-specific questions, contact Genova Diagnostics by calling 800-522-4762 or chatting with support.

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