Test Details

Lab Company: Genova Diagnostics
Sample Type: Urine
Collection Location: At Home

The Metabolomix+ analyzes nutritional biomarkers to assess the need for nutritional supplements and digestive support.    

🔑 Key Details 📦 Shipping
Preparation & Timing 📊 Results
🧪 Collection Instructions 📚 More Resources
💳 Requisition & Payment
💬 Questions?

Key Details 

  • Do NOT register your test online with Genova.
  • Do not collect while menstruating.
  • Avoid extreme diets and over-consuming any one food for 24 hours prior to sample collection. 
  • You must fast overnight prior to sample collection.
  • You must avoid certain activities on the morning of sample collection.
  • Collect your sample immediately upon waking.
  • Collect your samples all on the same day.

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Preparation & Timing

  • Do not collect while menstruating.
  • Consult your healthcare provider prior to testing if you have abnormal kidney function or take any of these medications. They may affect test results.
    • Diuretics
    • Valproic acid
    • Acetaminophen
    • Berberine HCl
  • 4 days before the test 
    • Your physician may want you to discontinue nonessential supplements and medications. 
    • Consult your physician before discontinuing any medications.
  • 24 hours before collection
    • Eat your usual diet.
    • Avoid over-consuming any one food or consuming any extreme diet.
    • Limit fluid intake to 48 oz over the whole 24 hour period. 
  • The night before collection
    • Fast overnight. You may drink water during the fast.
  • The morning of collection
    • Collect sample immediately upon waking. 
    • Avoid the following activities: 
      • Eating
      • Drinking anything but water
  • If you have any add-ons, you will collect all of your samples on the same day. 
    • Comprehensive Urine Elements Profile - Urine 
      • This test will be analyzed from the same urine sample as the main Metabolomix+ test.
    • Toxic Element Clearance Profile - Urine
      • This test will be analyzed from the same urine sample as the main Metabolomix+ test.
    • Essential & Metabolic Fatty Acids Profile - Blood Spot
    • Genomic SNPs - Swab 

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Collection Instructions

  1. Write the following information on the labels.
    1. Your date of birth
    2. The date of collection 
  2. Attach a completed label to each of the urine tubes.
  3. If you wake to urinate during the night (within 6 hours of waking), collect the urine into the provided collection cup. 
    1. Do NOT fill the cup completely. 
    2. Place the lid on the cup.
    3. Refrigerate the sample until the morning.
  4. Upon waking, collect urine into the provided collection cup (the same one used overnight). 
  5. Pass any additional urine into the toilet.
  6. Use the pipette to transfer urine from the collection container into the four collection tubes
    1. Fill each tube nearly full.
  7. Recap the tubes tightly.
  8. Shake the tubes.
  9. Place the tubes into the biohazard bag with the absorbent pad.
  10. Freeze the four tubes and the provided freezer brick for at least 24 hours
  11. Collect the swab and/or blood spot samples (if ordered).

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Requisition & Payment

  • Your kit has been prepaid. You DO NOT need to pay anything extra.
  • Instructions on how to fill out your requisition can be found HERE (insurance pay) and HERE (cash pay).
    • Since you pre-paid for your tests, you do not need to fill in the payment information on any of these forms.
    • Do NOT register your test online with Genova.

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  • Ship samples Monday - Thursday only.
  • Ship samples within 24 hours of your final collection.
  • To prepare your samples for shipping,
    • Place the four tubes into the biohazard bag with the absorbent pad.
    • Freeze the tubes for at least 24 hours.
    • Place the frozen samples into the foam insulator box.
    • Place the frozen freezer brick into the foam insulator box.
    • Place the foam insulator box in the outer collection box.
    • Place the activation label card/test requisition form into the outer collection box.
    • If you have any of the add-on tests, please include the add-on samples in the collection box.
    • Place the outer collection box into the provided FedEx mailer.
  • Make a note of the tracking number so that you can track your sample back to the lab. 
  • Ship your samples via FedEx.
    • You can take your samples to the nearest FedEx location.
    • Do NOT place your samples in a drop box.
    • You can also schedule a FedEx pickup by calling 1-800-463-3339 or visiting their website

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  • Results should be released to your provider 7-21 business days after samples are received at the lab. We cannot guarantee processing time. 
  • Your provider will notify you when your results are in and schedule a follow-up appointment for you to review them together. 
  • Your provider may choose to release your results to you. Rupa cannot release your results without provider authorization.

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More Resources

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For general questions, email Rupa Health at For test-specific questions, contact Genova Diagnostics by calling 800-522-4762 or chatting with support